Eating fewer calories and following certain diets can have a positive impact on the aging process and life span, previous research has shown. A new study using a mouse model found that while eating less may help extend life span, those that lived the longest on a calorie-restricting diet lost the least amount of weight. Researchers from The Jackson Laboratory and Calico Life Sciences discovered that genetic factors may play a larger role in longevity than diet.
The study, published in Nature, involved 960 genetically diverse female mice assigned to various diets, including caloric restriction and intermittent fasting. Results showed that mice on caloric restriction lived the longest, with those eating 80% of their usual calories living an average of 30 months. Additionally, mice that naturally maintained their body weight and fat percentage during periods of reduced food intake and stress lived the longest.
Genetic factors, such as genetically encoded resilience, were found to be more influential in longevity than diet in the mouse model. While caloric restriction is known to extend life span in rodents, researchers were surprised to find that weight loss did not necessarily translate to longer life span in this study. The study’s lead author emphasized that diets are not magic bullets and that other factors contribute significantly to life span.
Dr. Mir Ali, a board-certified surgeon, noted that the study’s findings about lower calories increasing life span without necessarily leading to weight loss were counterintuitive. While animal studies provide valuable insights, further research is needed to determine if these results translate to humans. Ali stressed the importance of maintaining a healthy weight and eating a balanced diet to maximize genetic potential and improve longevity.
Registered dietitian nutritionist Monique Richard suggested meeting with an RDN to understand individual dietary needs and prevent unhealthy eating habits. Optimizing diet by ensuring adequate nutrient intake and balanced distribution is key to supporting cellular functions and increasing the likelihood of a longer life span. The body functions best when supplied with the right nutrients in appropriate amounts and intervals, similar to a well-maintained machine operating at peak performance.
