Recent research has shown that more than half of people who are prescribed weight loss drugs such as Wegovy or Saxenda stop taking them within 12 weeks or earlier. A study conducted by Blue Shield found that 30% of individuals stop using these medications within the first four weeks, before reaching the target dose. Weight loss experts emphasize the importance of long-term use of weight loss drugs in order to achieve maximum benefits. Unfortunately, less than half of those prescribed drugs like Wegovy and Saxenda continue to take them for 12 weeks or more.
Wegovy and Saxenda are GLP-1 antagonists that mimic a hormone in the body called glucagon like peptide (GLP-1). These medications work by regulating blood sugar, reducing hunger, and increasing feelings of fullness. However, it typically takes at least 5 months for the drugs to reach their effective dose, and longer-term use is necessary for maintenance of weight loss and reduction of cardiometabolic diseases associated with obesity.
Despite the benefits of weight loss drugs, many people discontinue their use due to various reasons such as disease bias or stigma, supply constraints, access issues, and side effects. Novo Nordisk, the manufacturer of Wegovy and Saxenda, emphasizes the importance of long-term treatment for obesity, noting that the condition requires ongoing medical management similar to other chronic diseases like high blood pressure and high cholesterol.
In the United States, obesity is a prevalent issue with 73% of adults being overweight or obese. Nearly half of adults are interested in taking prescription weight loss drugs if they are safe and effective. These medications are intended for individuals with a body mass index of 30 or greater, or 27 or greater with related health issues. While weight loss medications can be beneficial for some, they may not be suitable for individuals who do not have a true medical need for them.
Despite the potential benefits of weight loss drugs, challenges such as cost, healthcare access, and side effects can lead to discontinuation of treatment. Research shows that individuals who are prescribed weight loss medications by specialists such as obesity medicine specialists or endocrinologists are more likely to continue taking the medications for longer periods. Experts stress the importance of long-term use of weight loss medications in order to achieve sustained weight loss and prevent weight regain once treatment is stopped.
