The University of Florida researchers found that an extract made from orange peels may help improve heart health in male mice. In the past few years, research focusing on the interactions between the gut microbiome and overall health has increased. The gut microbiome is linked to cholesterol metabolism, which plays a role in heart disease. Previous studies have shown that consuming certain foods such as blueberries, legumes, chia seeds, and leafy greens can improve cardiovascular health. The new study, published in the Journal of Agricultural and Food Chemistry, focused on an organic compound called trimethylamine N-oxide (TMAO) produced by gut bacteria. TMAO is associated with an increased risk for heart conditions, chronic kidney disease, and colorectal cancer.
The researchers at the University of Florida discovered that orange peel extract can inhibit the production of TMAO in the gut microbiome. Nearly all of Florida’s oranges are used to make orange juice, and the orange peels are usually discarded or used as cattle feed. The extract from orange peels contains chemicals that can improve heart health. Oranges are rich in antioxidants, potassium, and fiber, all of which are linked to a lowered risk for heart disease. Two types of orange peel extracts were tested, with the non-polar fraction being able to stop the production of TMAO in male mice. The polar fraction contained a compound called feruloylputrescine, which inhibited the enzyme responsible for producing TMA, a precursor to TMAO.
The study highlights the complex interactions between the gut microbiome and cardiovascular health. Understanding how the gut processes foods to produce compounds that affect human health is crucial. Consuming citrus fruits, including oranges, can provide beneficial compounds for heart health. Citrus fruits are rich in antioxidants, polyphenols, and vitamin C, which support gut health and may improve heart health. However, orange peel extract and orange juice may interact with certain medications, so it is important to be cautious when incorporating them into the diet. Organic, washed orange peels can be added to various dishes to benefit from their health properties.
Incorporating a variety of citrus fruits into the diet can support gut and heart health while providing vibrant flavors and smells. Orange peels can be used in cooking, teas, sauces, smoothies, and desserts to boost heart health. Adding citrus fruits with their pulp can provide prebiotics for beneficial gut bacteria. Overall, taking advantage of the health benefits of citrus fruits and orange peels can improve overall health and vitality.
