By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Gulf PressGulf Press
  • Home
  • Gulf News
    • Saudi Arabia
    • UAE24/7
    • Kuwait
    • Qatar
    • Bahrain
    • Oman
  • World
  • Business
    • Market DataLive
    • Finance
    • Economy
    • Energy
    • Crypto
    • ForexHot
    • Tech
  • Sports
  • Lifestyle
  • Videos
Search
Countries
  • Saudi Arabia
  • UAE
  • Kuwait
  • Qatar
  • Bahrain
  • Oman
More Topics
  • Technology
  • Health
  • Entertainment
  • Crypto
  • Forex
  • Stocks
Site Links
  • Business Hub
  • Trending
  • Weather
  • Customize Interests
  • Bookmarks
  • Newsletter
  • Terms
  • Press Release
  • Advertise
  • Contact
© 2023 Gulf Press. All Rights Reserved.
Reading: Increased salt consumption connected to higher risk of autoimmune diseases
Share
Notification Show More
Latest News
UAE Ranks Among Top Rugby Markets on TOD as British & Irish Lions Tour Kicks Off
Sports
Darven: A New Leap in AI-Powered Legal Technology Launching from the UAE to the World
Tech
Beat the Heat This Summer with a Chill Out on Dubai Marina
World
Historic Italian City of Assisi to Host International Exhibition “Jordan: Dawn of Christianity”
World
Jordan to Host Iraq in the Final Round of the Asian World Cup Qualifiers After Securing Historic Spot
Sports
Aa
Gulf PressGulf Press
Aa
  • Gulf News
  • World
  • Business
  • Entertainment
  • Lifestyle
  • Sports
  • Videos
Search
  • Home
    • Videos
    • Business Hub
    • Trending
  • Gulf
    • Saudi Arabia
    • UAE
    • Kuwait
    • Qatar
    • Bahrain
    • Oman
  • Business
    • Market Data
    • Crypto
    • Economy
    • Energy
    • Finance
    • Forex
    • Tech
  • More News
    • World
    • Lifestyle
    • Entertainment
    • Sports
Have an existing account? Sign In
Follow US
  • Terms
  • Press Release
  • Advertise
  • Contact
© 2023 Gulf Press. All Rights Reserved.
Gulf Press > Health > Increased salt consumption connected to higher risk of autoimmune diseases
Health

Increased salt consumption connected to higher risk of autoimmune diseases

News Room
Last updated: 2024/09/04 at 5:33 PM
News Room
Share
3 Min Read
SHARE

Multiple sclerosis (MS) is a chronic autoimmune disease caused by the interaction between environmental factors, such as high dietary salt intake, and genetic risk factors. Regulatory T cells, which suppress an immune response against the body’s own tissue, can malfunction, leading to the development of MS and other autoimmune diseases. A recent study shows that high sodium levels lead to the upregulation of a molecular pathway involving the SGK-1 and PRDM1-S genes, causing regulatory T-cell dysfunction. This study reveals a potential mechanism by which a high-salt diet could increase the risk of autoimmune diseases.

Dr. Tomokazu Sumida, a professor at Yale School of Medicine and the lead author of the study, explained that previous research has shown that regulatory T cells are defective in autoimmune diseases such as multiple sclerosis, suggesting their critical role in disease development. The study uncovers the underlying mechanism responsible for the loss of immune regulation in MS, linking environmental and genetic factors. The researchers also identify a novel target for treating autoimmune diseases, shedding light on potential future therapeutic approaches.

Multiple sclerosis affects nearly 2.8 million individuals worldwide, with the immune system attacking myelin, the protective sheath covering nerve fibers. Dysfunction of immune cells, including regulatory T cells, leads to an immune response against the body’s own cells and tissues. The study compared differences in gene expressions in regulatory memory T cells from individuals with MS and healthy controls, revealing alterations in the PRDM1 and SGK-1 genes that contribute to regulatory T-cell dysfunction.

PRDM1-S, a gene encoding a protein that regulates regulatory T-cell function, was found to be overexpressed in MS individuals, leading to an increase in SGK-1 expression and decreased suppressive function of regulatory T cells. The PRDM1-S/SGK-1 pathway was identified as a common molecular mechanism underlying regulatory T-cell dysfunction in autoimmune diseases, suggesting a potential target for new therapeutic strategies. High dietary salt intake, associated with an increased risk of autoimmune diseases, activates this pathway, contributing to regulatory T-cell dysfunction in conditions such as MS.

The study highlights the potential of targeting the PRDM1-S/SGK1 axis in susceptible MS patients to prevent disease onset and progression. By understanding the molecular pathways involved in regulatory T-cell dysfunction, researchers hope to develop more effective therapies for autoimmune diseases. Further research is needed to explore the role of PRDM1-S in other cell types and its associations with viral infections and cancer progression, expanding the knowledge of autoimmune mechanisms and potential treatment options. Overall, this study offers valuable insights into the pathogenesis of MS and other autoimmune diseases, paving the way for future research and therapeutic advancements.

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
I have read and agree to the terms & conditions
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
News Room September 4, 2024
Share this Article
Facebook Twitter Copy Link Print
Previous Article Robinson predicts English fans will target Grealish with abuse from Irish fans – News
Next Article MHT organizes discussions with European tourism companies at ‘Marhaba Europe’ event
Leave a comment Leave a comment

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Stay Connected

235.3k Followers Like
69.1k Followers Follow
56.4k Followers Follow
136k Subscribers Subscribe
- Advertisement -
Ad imageAd image

Latest News

UAE Ranks Among Top Rugby Markets on TOD as British & Irish Lions Tour Kicks Off
Sports July 6, 2025
Darven: A New Leap in AI-Powered Legal Technology Launching from the UAE to the World
Tech July 1, 2025
Beat the Heat This Summer with a Chill Out on Dubai Marina
World July 1, 2025
Historic Italian City of Assisi to Host International Exhibition “Jordan: Dawn of Christianity”
World June 28, 2025

You Might also Like

Health

Mindfulness could be equally effective as antidepressants

October 17, 2024
Health

What is the impact of caffeine on the risk of developing diseases?

October 17, 2024
Health

Scientists discover combination of 14 genes that enhance outcomes

October 16, 2024
Health

Seizure medication demonstrates potential in individuals with no genetic risk

October 16, 2024
Health

Heart disease increases risk, heparin can postpone onset

October 16, 2024
Health

What type of breakfast is most effective for weight loss in women compared to men?

October 15, 2024
Health

How does the brain remove “waste” to protect itself?

October 14, 2024
Health

How does stress, sleep, and gut imbalances affect it?

October 13, 2024
//

Gulf Press is your one-stop website for the latest news and updates about Arabian Gulf and the world, follow us now to get the news that matters to you.

Quick Link

  • Privacy Policy
  • Terms of ue
  • Advertise
  • Contact

How Topics

  • Gulf News
  • International
  • Business
  • Lifestyle

Sign Up for Our Newsletter

Subscribe to our newsletter to get our latest news instantly!

I have read and agree to the terms & conditions
Gulf PressGulf Press
Follow US

© 2023 Gulf Press. All Rights Reserved.

Join Us!

Subscribe to our newsletter and never miss our latest news, podcasts etc..

I have read and agree to the terms & conditions
Zero spam, Unsubscribe at any time.

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?