Folates, also known as vitamin B9, play a crucial role in early life but may pose metabolic challenges for individuals from middle age onward, according to a recent study. Research conducted on older mice discovered that lowering folate consumption allowed them to transition more easily between fat-burning and carbohydrate-burning modes of metabolism. Even though folates are essential for healthy blood, the older mice in the study did not show signs of developing anemia. This study builds upon similar findings in yeast cells and worms, indicating a potential connection between folate intake and metabolic issues in older individuals.
A new study from Texas A&M University’s AgriLife Research suggests that reducing folate levels, the natural form of vitamin B9, may aid in the switch from sleep metabolism to waking metabolism in middle-aged mice. When individuals and mice are asleep, their metabolisms focus on burning body fat, while waking hours involve burning carbohydrates for energy. Previous research involving reduced folate intake in yeast cells and worms showed increased longevity compared to control groups who consumed typical amounts of folates. The recent study focused on middle-aged mice and found that those on a folate-deficient diet did not develop anemia and showed no decrease in viability or body weight.
Folates are essential for various bodily functions such as DNA synthesis, cell repair, and red blood cell production. While they are crucial during periods of rapid growth like pregnancy and infancy, folates are also important for adults to support cell function, prevent anemia, and promote cardiovascular health. Foods rich in folates include asparagus, avocados, chickpeas, leafy greens, liver, peas, and spinach. Interestingly, the study raises questions about how folate-deprived mice maintained sufficient red blood cell levels without developing anemia. It is likely that their gut bacteria played a role in providing necessary folate levels.
While folates are important nutrients for overall health, especially cardiovascular well-being, it is essential to follow dietary guidelines and consult with a healthcare professional for personalized advice. The study’s findings in mice suggest the potential for folate reduction in older individuals to improve metabolic flexibility and overall health. Maintaining a healthy gut microbiome is also crucial for ensuring adequate vitamin levels and preventing associated health issues. Further research is needed to confirm these findings before making recommendations for changes in older adults’ diets. In the future, a folate-reducing additive could be a simple way for middle-aged and older individuals to adjust their folate intake based on their specific needs.
