A recent study has found that both obesity and metabolic syndrome have distinct but significant effects on breast cancer risks. Researchers discovered that a higher metabolic score is associated with increased mortality from breast cancer, while obesity is linked to a higher incidence of the disease. The study, which followed over 63,000 women for about 20 years, focused on the impact of these two factors on postmenopausal breast cancer.
The research highlighted that a high metabolic score, which includes factors like waist circumference, blood sugar, blood pressure, and cholesterol, was associated with more poor-prognosis estrogen-receptor-positive, progesterone receptor-negative breast cancers. On the other hand, obesity was found to be connected to a higher overall rate of breast cancer, including more favorable estrogen-receptor-positive, progesterone receptor-positive breast cancers. Additionally, obesity was linked to an increased risk of death following a breast cancer diagnosis, particularly in women with severe obesity.
The study also emphasized the importance of lifestyle factors in reducing breast cancer mortality. A low-fat diet was shown to have a positive impact on breast cancer outcomes, especially in women with metabolic syndrome components such as obesity, hypertension, high blood pressure, elevated blood sugar, and abnormal cholesterol levels. The researchers suggested that targeting obesity and metabolic syndrome could lead to a significant reduction in breast cancer risk and mortality rates.
Experts not involved in the study emphasized the need for preventive strategies to address the impact of obesity and metabolic syndrome on breast cancer. They highlighted the importance of maintaining control over factors like glucose levels, blood pressure, and cholesterol through lifestyle changes and medications to lower the risk of developing more aggressive types of breast cancer. Primary care physicians and OB/GYNs were identified as key players in promoting breast cancer prevention through discussions about diet, lifestyle, and risk factors.
Overall, the findings from this study underscore the complex relationship between obesity, metabolic syndrome, and breast cancer. While both risk factors play a role in increasing the burden of breast cancer, efforts focused on improving metabolic syndrome components may have a greater impact on reducing breast cancer mortality. By addressing modifiable risk factors and promoting healthy lifestyle choices, individuals can take proactive steps to lower their risk of developing and experiencing negative outcomes from breast cancer.
